ANALYSIS OF PARB-CENTROMERE INTERACTIONS BY MULTIPLEX SPR IMAGING REVEALS SPECIFIC PATTERNS FOR BINDING PARB IN SIX CENTROMERES OF BURKHOLDERIALES CHROMOSOMES AND PLASMIDS.

Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids.The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons.Closely related f

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Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature

Upper tract urothelial carcinoma (UTUC) is less common than bladder cancer, but its incidence is increasing.Neoadjuvant chemotherapy (NAC) has been the treatment focus for locally invasive and high-grade UTUC.Herein, we aimed to present a case of a locally advanced non-metastatic UTUC, which was thought to be unresectable due to local invasion, but

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Undocumented Americans Need Equitable Language in Worker Training

Dear Editor: Undocumented immigrant American workers face barriers to adequate safety training and disparities in occupational health.1 The workplace plays a vital role in the lives of all Americans who perform the necessary work that keeps society functioning, including undocumented workers.It is important that workers receive training and educati

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